MLB betting action kicks off its first weekend of Interleague play beginning this weekend, and several of the best matchups of the entire year between the American and National Leagues will be underway. Here at Bankroll Sports, we’re taking a look at some of the teams that you need to keep an eye on as the two leagues collide with one another beginning on Friday!

New York Yankees: The Bronx Bombers not only have the second best record in baseball at 25-13 coming into Tuesday, but they also have the best all-time record in Interleague play as well at 133-95. They went just 10-8 in 18 Interleague clashes last season, but their record against their cross town rivals from Flushing was an impeccable 5-1. The Yanks outscored the Mets 18-3 in a three game sweep at the end of June last year, and outscored them by another 26-14 margin over Father’s Day weekend at Yankee Stadium. Who could forget closer Francisco Rodriguez throwing his arms in the air after inducing a pop up to 2B Luis Castillo for what should’ve ended the game? It did. Castillo dropped the ball, two runs scored, and the Yanks won 9-8.

Florida Marlins: It feels like we talk about the Marlins posting solid records every year in Interleague play. They have the best record amongst the National League squads all-time at 120-99 in 219 cross-league battles. Last season, no one in the NL had a better team batting average than the Fish did in Interleague play (.280), and their 78 runs scored was second in the NL. Florida finished a solid 10-8. This weekend, it will face off with the Chicago White Sox, a team that it has faced six times in team history. The Marlins took too out of three games from the Pale Hose both in 2007 at US Cellular Field and in 2004 in South Beach. Florida has won six of its L/10 games overall and is a game over .500 coming into Tuesday’s action, so expect to see the Fish try to make a move during their best time of year.

Colorado Rockies: The Rocks rolled to an 11-4 record in Interleague play last season as a part of their most improbable comeback from the depths of the NL West to the make the postseason. They’ve got a fantastic draw at the start of Interleague play this season, getting to travel to a Kansas City team that is a mess at this point after the firing of manager Trey Hillman. Colorado had won four of its previous five games before losing the first game of a series at Wrigley Field on Monday night, but it is still just four games back in the tightly contested NL West race. The only concern about the Rockies in this one is that they have actually never won a game at Kauffman Stadium, going 0-3 all-time there from a series sweep in 2008. The team may be five games under .500 all-time in cross-league play, but Colorado is still a team to watch to make a move over this summer.

Los Angeles Angels of Anaheim: Manager Mike Scioscia had better hope that his team can come back from the depths of obscurity in the AL West race with a strong Interleague season! The Halos are just 18-22 through 40 games and are in dire need of a winning streak to get back in contention in the divisional race. No one posted a better Interleague mark in the bigs last year than did the Angels, who went a whopping 14-4. This will be the third trip to Busch Stadium for Anaheim in team history (ironically, the Cardinals have never traveled to the Big A). The Halos have captured three of the L/4 meetings and are an even 3-3 in six games against the Redbirds all-time. With a .557 winning percentage all-time in Interleague play, Scoscia’s boys aren’t ones to mess around with.