A great week on the Week 4 NFL betting lines is already getting started here at Bankroll Sports, and we are zeroing in on the best and the brightest NFL betting lines that are on the board for the week ahead!

Note: All NFL betting lines listed for the purposes of this article were posted at 6:00 p.m. ET on Sunday, 9/22. For the most up to date Week 4 NFL Vegas odds, please check below

Week 4’s Thursday Night Football game is going to be a doozy of a battle, as the San Francisco 49ers are going to take on the St. Louis Rams. These two teams could go back and forth with each other in the NFC West all season long. This is a crucial one for San Fran especially, which already lost a road game in division once this year from just two weeks ago. QB Colin Kaepernick and the gang have still looked good aside from that game against the Seahawks, but this is a big test on the road against a team that is ready for a bounceback after losing two straight suspect games. If St. Louis is going to get back into the chase in the NFC West, this is a game that it has to win. However, the Week 4 odds suggest that the 49ers are going to end up being at their best in this one, as they are favored by 3.5.

Fast forwarding to Sunday, we see that there are plenty of games that are expected to be close. In fact, there is only one game on the NFL opening lines where one team is favored by more than 7.5 points over another team, and that’s the clash on the road when the Denver Broncos take on the Philadelphia Eagles. QB Peyton Manning and the gang have looked great through two games thus far this year, and this should merely be a bump in the road. We’ll have to see how Head Coach Chip Kelly can get his team ready with an extended week of practice. Remember that this is the first time this year that the Eagles are playing a game on more than just five days of rest plus a day of travel, and they could be much better because of it. That said, going all the way to Mile High isn’t going to be fun for anyone this year, and it’s not surprising that in spite of that fact, the Eagles are getting 13. It’s going to be tough for this offense to get going in the thin air unless it is appropriately trained, and this is one thing that Kelly and QB Michael Vick couldn’t possibly be getting ready for in the City of Brotherly Love.

The only other game featuring NFL point spreads of greater than 6 is when the Indianapolis Colts, who look much better offensively with RB Trent Richardson in the fold, head to the Sunshine State to take on the Jacksonville Jaguars. Jacksonville has now been blown out by double digits in three straight games to start the season, and there is no turning back in this one. The Jags are +7.5, and this is a number that could get worse as the week goes on.

The one common thread that is apparent in Week 4 is the fact th that there are a ton of games that feature road favorites of varying degrees. We’ve already spoken about the Colts, but the Cincinnati Bengals are -5 at the Dawg Pound against the suddenly inspiring Cleveland Browns. Leave it up to Cleveland to trade its best player in RB Trent Richardson and find a way to win the next week with a backup quarterback. QB Brian Hoyer threw for 321 yards and three TDs last week, and that might create some real quarterback controversy for the Browns regardless of whether QB Brandon Weeden is healthy or not. Cincy is -5, but these divisional road games are always particularly tough, especially in the AFC North.

The Baltimore Ravens, fresh off of their upset over the Houston Texans last week, are going to be heading on the road this week to take on the Buffalo Bills, who badly need a win if they are going to stick around as potential contenders for the playoffs in the AFC. Baltimore is giving 4.5-points in spite of the fact that its offense really hasn’t done all that much impressive this year.

Perhaps the oddest spots for road favorites this week are on the West Coast against AFC West teams. Oh sure, the Dallas Cowboys have done everything that they can to deserve being -2 against the San Diego Chargers, but an 0-3 team traveling across the country is a favorite? That’s the situation that the Washington Redskins are in against the Oakland Raiders. Be very wary of this one, especially knowing that the buzzards are already starting to swarm around Head Coach Mike Shanahan.

The best game of the day on Sunday featuring a road favorite is the clash between the Seattle Seahawks and the Houston Texans. The Seahawks are looking the part of the best team in football right now, but this is a tough road trip against a Houston team that needs to prove that it can stick with the big boys. Remember last season when the Texans beat up the Ravens by 30 at home? This could be the same type of game if the Seahawks aren’t careful. That said, even on the road, Seattle is giving a field goal, and that could be a recipe for disaster for the visitors.

Elsewhere on Sunday on the NFL betting lines… The Tampa Bay Buccaneers are -3 against the Arizona Cardinals. The Kansas City Chiefs are six-point favorites to improve to 4-0 against the already 0-3 New York Giants. The Tennessee Titans are -5.5 at home against the New York Jets as well.

Sunday Night Football in Week 4 pits the New England Patriots up against the Atlanta Falcons. The Falcons still don’t totally look right, but they are going against a New England team that really hasn’t faced any quality opponent this year. On the road in primetime is going to be quite the test for QB Tom Brady and the gang, though we fully expect to see TE Rob Gronkowski back in this game for the Pats. That could be the great equalizer. New England is just a pick ’em in this clash of two teams that were expected to challenge on the Super Bowl odds this year.

On Monday Night Football, the New Orleans Saints are giving 4.5 to the Miami Dolphins. These two teams both missed out on the playoffs last year, but there is no doubt that both teams are going to be in a position to challenge this year in their respective divisions. Points could be aplenty in this one, especially knowing that QB Drew Brees is just 300 passing yards away from tying the record for the most consecutive 300+ yard games in NFL history. Brees is currently at eight. The NFL record is nine.

2013 NFL Week 4 Odds @ BetOWI Sportsbook (as of 9/25/13):
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Week 4 NFL Point Spreads for Thursday, September 26th
101 San Francisco 49ers -3
102 St. Louis Rams +3
Over/Under 42

Week 4 NFL Spreads for Sunday, September 29th (1:00 ET Kickoffs)
199 Pittsburgh Steelers -2.5
200 Minnesota Vikings +2.5
Over/Under 42

201 Baltimore Ravens -3
202 Buffalo Bills +3
Over/Under 44.5

203 Cincinnati Bengals -4
204 Cleveland Browns +4
Over/Under 42

205 Indianapolis Colts -7.5
206 Jacksonville Jaguars +7.5
Over/Under 42.5

207 Seattle Seahawks -2.5
208 Houston Texans +2.5
Over/Under 41.5

209 Arizona Cardinals +2
210 Tampa Bay Buccaneers -2
Over/Under 41

211 Chicago Bears +3
212 Detroit Lions -3
Over/Under 47.5

213 New York Giants +4.5
214 Kansas City Chiefs -4.5
Over/Under 44

NFL Week 4 Betting Lines for Sunday, September 29th (4:00 ET Kickoffs)
215 New York Jets +3.5
216 Tennesese Titans -3.5
Over/Under 39

217 Dallas Cowboys -2
218 San Diego Chargers +2
Over/Under 46.5

219 Washington Redskins -3
220 Oakland Raiders +3
Over/Under 43.5

221 Philadelphia Eagles +11
222 Denver Broncos -11
Over/Under 57.5

Sunday Night Football Week 4 Odds for Sunday, September 29th
223 New England Patriots +2
224 Atlanta Falcons -2
Over/Under 49.5

Monday Night Football Week 4 Lines for Monday, September 30th
225 Miami Dolphins +6.5
226 New Orleans Saints -6.5
Over/Under 48

Week 5 NCAA football odds are posted here at Bankroll Sports, and we are already set to break down some of the best games on the college football betting lines for the week ahead. Join us as we take our best shot at the NCAA football Vegas odds in Week 5.

First off, we can really be thankful over the fact that this isn’t a week in which there are a ton of dog games like there were last week. We have some real marquee battles all across the board, and there are a lot of Top 25 teams on upset alert, unlike last week, when the entire Top 25 managed to hold firm, save for Stanford and Michigan State losing games against other ranked teams. In fact, there isn’t a single game pitting an FCS and an FBS team against each other for the first time all season long, and that should make for much better football.

We’ll start on Thursday and Friday with all of the midweek games. Over in the ACC, there is a crucial game on Thursday, as the Virginia Tech Hokies and the Georgia Tech Yellow Jackets face off with one another. There is a good chance that this could act as an elimination game in the ACC Coastal Division race, especially if G-Tech, which has already beaten North Carolina and Duke, turns out to be victorious. Head Coach Frank Beamer and his Hokies haven’t looked all that sharp over the course of the last week or two, but they are winning games, something more than what we could say about a lot of other teams across the country, specifically in the ACC. Georgia Tech is giving 7.5 in this one, and that’s a heck of a lot of points to be giving in the ACC, especially in the Coastal Division where things couldn’t quite possibly be any tighter than they already are.

The Iowa State Cyclones have yet to win a game this year, but they are going to have a puncher’s chance in this one on the road against the Tulsa Golden Hurricane in a rare situation where a big time conference school has to go on the road to take on a Conference USA team. We haven’t seen a lot of luck for the big boys in this situation yet this year, especially out of the bottom of the Big XII, and the oddsmakers are quite aware of that. ISU is getting a field goal in this one against the Golden Hurricane, who in their own right, only have one victory

On Friday, there is a great game out of the MWC, as the San Jose State Spartans play host to the Utah State Aggies. San Jose State is a team that we remain high on in spite of the fact that it is only 1-2 on the season, and it has a chance to make a name for itself on national television on Friday night against Utah State. The Aggies have the names attached to them, including QB Chuckie Keeton, who figures to be one of the top players in the conference this year. Utah State is giving 9.5 on the road, but that could be a grossly overstated number, knowing that these two teams are very familiar with one another having played all those years in the WAC before transferring over.

In the final Friday nighter, the BYU Cougars are giving 21 to the Middle Tennessee State Blue Raiders.

Perhaps the best news is the fact that the 21 points being laid in that game between BYU and MTSU is one of the higher spreads of the weekend. At least as of this point, the only team that is favored by more than four touchdowns is the Oregon Ducks. The Quack Attack is excellent and is running up the score against anyone and everything that it faces. Now, it gets to take on a very similarly constructed Cal Golden Bears outfit that doesn’t nearly have the same type of athletes on it. QB Marcus Mariota and the gang should be in for a big time day for sure against what should be a challenged Cal team defensively, and that’s why the Ducks are laying 35.5.

There are some big road favorites that deserve to be pointed out. The Florida State Seminoles, who have destroyed all of their foes this year, are -21.5 on the road in their second conference game against the Boston College Eagles, while the Oklahoma State Cowboys are -21 on the road against the offensively challenged West Virginia Mountaineers. Why are these two games so notable? They’re the only ones on the whole slate where road teams are favored by more than 18 points. There are also only a total of six games on the docket right now that feature double digit road favorites, though there are teams like the Texas A&M Aggies, Miami Hurricanes, and Fresno State Bulldogs who will all open up as double digit chalks in all likelihood on the Week 5 NCAA football betting lines.

Last week, the Top 25 teams were favored by an average of 19 points per game, and a ton of them were laying 30 and 40 points and successfully covering in doing so. This time around, there are a slew of Top 25 teams that have to go on the road, many of which are in very dangerous situations.

The UCF Knights are looking to win what might be the biggest game in their history when they host the South Carolina Gamecocks at Bright House Networks Stadium. In spite of the fact that UCF isn’t a Top 25 team at this point, it is still a club that is getting a lot of respect from the oddsmakers. The Gamecocks are only +7.5 and are already dropping as the week starts off, and we are very aware that this could be a game where a Top 15 team in the land is on upset alert. The #14 Oklahoma Sooners could also be in some trouble when they hit the road to take on the Notre Dame Fighting Irish, who have failed to cover two straight games here in South Bend. The boys from Norman are expected to win and are -3 in this one, but we know that this is a game that really could end up going either way.

But of course, when you’re talking about the games of the day, there is no doubt that there are two games that everyone is going to be talking about. In the evening, the Ohio State Buckeyes and the Wisconsin Badgers are going to have at it in the Big Ten Leaders Division. Most essentially figure that this is the Leaders Division title game at this point, and with the Penn State Nittany Lions ineligible for the postseason, there is no doubt that the winner of this game is heading to Detroit for the conference title game barring an epic collapse with multiple losses. Ohio State still might not have QB Braxton Miller, who has been battling a knee injury, but the oddsmakers obviously have the confidence that this team is no worse with QB Kenny Guiton calling the shots if that’s what it comes to. We have to think that Miller is going to be back under center for the biggest game of the year in what might be one of the few games separating OSU from a trip to the National Championship Game. The Buckeyes are -7.5 on the opening college football Vegas odds.

The other game of course, is the big one out of the SEC. The LSU Tigers are going on the road to take on the Georgia Bulldogs, and there is no doubt that this is a personal game. QB Zach Mettenberger was kicked out of Athens early in his collegiate career, and he found a home here in the Bayou. LSU has taken a meteoric rise through the rankings over the course of the first four weeks of the season, and it is a team that many think can win this one “Between the Hedges.” It’s a game that could be dangerous for the Dawgs, who can’t afford another loss if they think they are going to contend for the National Championship, but it is every bit as big of a game for LSU, a team that many think could win the whole enchilada this year. LSU is getting 3.5 at the open, but the college football betting lines in this one are going to be flying all over the place.

These aren’t the only really important games of the day by any stretch of the imagination. The Alabama Crimson Tide aren’t expected to be tested until the Bayou Bengals come to Tuscaloosa, but they had better not overlook the Ole Miss Rebels. The Rebs are hungry and they have already proven that they can go on the road and win some games this year. Ole Miss is getting 17, and many think that this could be a game very similar to last season’s game against QB Johnny Manziel and the Texas A&M Aggies. QB Bo Wallace could be a dark horse Heisman Trophy candidate, and if he can pull off the upset in this one, you can bet that you’ll be hearing many talk about him throughout the weeks to come.

Over in the Pac-12, the Stanford Cardinal are -10 on the road against the Washington State Cougars in an important game, while the Arizona Wildcats are getting a touchdown on the road in Seattle against the Washington Huskies.

The lowest ‘total’ of the week is right off of the bat on Thursday night between G-Tech and V-Tech. The number of 43 is almost as low as any number that we have seen all season long. However, on the flip side of that, Oregon and Cal are featuring an 84 on the board right now, and that’s the highest ‘total’ that we have ever seen in a game.

2013 NCAA Football Week 5 Odds @ WagerWeb Sportsbook (as of 9/25/13):
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Week 5 NCAA Football Betting Lines for Thursday, 9/26/13
103 Virginia Tech Hokies +7
104 Georgia Tech Yellow Jackets -7
Over/Under 43.5

105 Iowa State Cyclones +2.5
106 Tulsa Golden Hurricane -2.5
Over/Under 55

College Football Lines for Week 5 for Friday, 9/27/13
107 Middle Tennessee State Blue Raiders +23
108 BYU Cougars -23
Over/Under 59.5

109 Utah State Aggies -9.5
110 San Jose State Spartans +9.5
Over/Under 61.5

NCAA Football Week 5 Odds for Saturday, 9/28/13
111 Virginia Cavaliers +5
112 Pittsburgh Panthers -5
Over/Under 51.5

113 Northern Illinois Huskies -3.5
114 Purdue Boilermakers +3.5
Over/Under 58

115 Troy Trojans +11
116 Duke Blue Devils -11
Over/Under 67.5

117 Connecticut Huskies pk
118 Buffalo Bulls pk
Over/Under 48.5

119 Toledo Rockets +2.5
120 Ball State Cardinals -2.5
Over/Under 67.5

121 Central Michigan Chippewas +23.5
122 NC State Wolfpack -23.5
Over/Under 52

123 Kent State Golden Flashes +2.5
124 Western Michigan Broncos -2.5
Over/Under 51.5

125 East Carolina Pirates +12.5
126 North Carolina Tar Heels -12.5
Over/Under 59

127 Florida State Seminoles -21.5
128 Boston College Eagles +21.5
Over/Under 52

129 UAB Blazers +19.5
130 Vanderbilt Commodores -19.5
Over/Under 55

131 Miami Redhawks +25
132 Illinois Fighting Illini -25
Over/Under 50.5

133 SMU Mustangs +19.5
134 TCU Horned Frogs -19.5
Over/Under 52

135 Arkansas State Red Wolves +21
136 Missouri Tigers -21
Over/Under 62.5

137 Iowa Hawkeyes -1
138 Minnesota Golden Gophers +1
Over/Under 46.5

139 UTEP Miners +13.5
140 Colorado State Rams -13.5
Over/Under 53.5

141 LSU Tigers +3
142 Georgia Bulldogs -3
Over/Under 61.5

143 Arizona Wildcats +10.5
144 Washington Huskies -10.5
Over/Under 64

145 Ole Miss Rebels +14.5
146 Alabama Crimson Tide -14.5
Over/Under 55.5

147 California Golden Bears +36
148 Oregon Ducks -36
Over/Under 84

149 USC Trojans +5.5
150 Arizona State Sun Devils -5.5
Over/Under 50.5

151 Army Black Knights -1.5
152 Louisiana Tech Bulldogs +1.5
Over/Under 55.5

153 Texas A&M Aggies OTB
154 Arkansas Razorbacks OTB
Over/Under OTB

155 Oklahoma Sooners -3.5
156 Notre Dame Fighting Irish +3.5
Over/Under 49.5

157 Southern Mississippi Golden Eagles +28
158 Boise State Broncos -28
Over/Under 55.5

159 Miami Hurricanes -18.5
160 South Florida Bulls +18.5
Over/Under 48

161 Wake Forest Demon Deacons +29
162 Clemson Tigers -29
Over/Under 58.5

163 Temple Owls -7.5
164 Idaho Vandals +7.5
Over/Under 57

165 Tulane Green Wave +14
166 Louisiana Monroe Warhawks -14
Over/Under 57

167 Houston Cougars -2.5
168 Texas San Antonio Roadrunners +2.5
Over/Under 63

169 Akron Zips +14.5
170 Bowling Green Falcons -14.5
Over/Under 53

171 Colorado Buffaloes +11
172 Oregon State Beavers -11
Over/Under 59.5

173 South Carolina Gamecocks -7
174 UCF Knights +7
Over/Under 53

175 Florida Gators -12.5
176 Kentucky Wildcats +12.5
Over/Under 46

177 Stanford Cardinal -10
178 Washington State Cougars +10
Over/Under 48

179 Wyoming Cowboys -11.5
180 Texas State Bobcats +11.5
Over/Under 55.5

181 Navy Midshipmen -3
182 Western Kentucky Hilltoppers +3
Over/Under 57.5

183 Florida Atlantic Owls +13.5
184 Rice Owls -13.5
Over/Under 52.5

185 South Alabama Jaguars +19.5
186 Tennessee Volunteers -19.5
Over/Under 53.5

187 Air Force Falcons +10
188 Nevada Wolf Pack -10
Over/Under 60.5

189 Oklahoma State Cowboys -18
190 West Virginia Mountaineers +18
Over/Under 57

191 Wisconsin Badgers +7
192 Ohio State Buckeyes -7
Over/Under 54.5

193 UNLV Runnin’ Rebels -3
194 New Mexico Lobos +3
Over/Under 54

195 San Diego State Aztecs -17
196 New Mexico State Aggies +17
Over/Under 54

197 Fresno State Bulldogs -18.5
198 Hawaii Warriors +18.5
Over/Under 58.5