This is one of the biggest weeks on the NCAA football odds all year long. There are three clashes of teams that are ranked in the Top 15 in the nation and a ton of other conference games that should whet your appetite. Don’t miss out on our 2012 Week 6 betting lines for college football!

But before we get to the main course on Saturday, we have five weekday games to sink our teeth into. The most important game on the college football gambling lines is the one between the USC Trojans and the Utah Utes. Anyone betting on the Men of Troy have to be careful, knowing that road teams have been as good as death, especially ones that are ranked in the Pac-12 this year. USC has already fallen victim to the Stanford Cardinal on the road, and the CFB point spread wasn’t really all that far off from this one. USC is getting the nod to start the week at -12.5.

Elsewhere on Thursday night, the UCF Knights are laying two touchdowns against the East Carolina Pirates, while the Arkansas State Red Wolves and the Florida International Golden Panthers aren’t going to be separated by all that much. The Red Wolves are 1.5-point underdogs on the road in South Florida.

Friday night is featuring a two-pack of games. The Big East kicks things off when the Pitt Panthers are favored by a field goal at the Carrier Dome against the Syracuse Orange. The BYU Cougars and Utah Utes will also face off on Friday night on ESPN, but the Week 6 odds are currently off the board at the start of the week.

There are three absolutely massive games that are on the docket this week that cannot be missed, as they all feature Top 12 teams.

We’ll start with the 3:30 ET game pitting the Florida Gators against the LSU Tigers. The Bayou Bengals have been falling in the Top 5 in the land over the course of the last few weeks. They have been playing very vanilla ball though, and they are going to have a real chance to shine in the Swamp against the Gators. Play this game two weeks ago, and the Gators are underdogs by at least a touchdown, and maybe double digits. Play in three weeks in the future, and that might be the case as well. However, with the Tigers playing seemingly as badly as they have over the course of the last few years and the Gators coming into this one at 4-0, and for those reasons, the men in blue and orange are only catching 3.5.

Later on in the night, the West Virginia Mountaineers, fresh off of their 800+ yard game, are going to be headed on the road to take on the Texas Longhorns. The Horns were able to come up with a game winning drive of their own against Oklahoma State last week. QB David Ash and QB Geno Smith are going to be fighting it out in this one in Austin, and it is going to be a Texas-sized showdown. This is inevitably going to be one of the biggest ‘totals’ of the week. The Mountaineers are the higher ranked team, but in the end, they aren’t expected to win this game, and the oddsmakers aren’t even implying that they are the better team. Texas is favored by 6.5.

But perhaps the biggest NCAA football matchup in Week 6 pits the Georgia Bulldogs against the South Carolina Gamecocks. Especially if Florida loses earlier in the day, this game will be for first place in the SEC East. This is a bigger game from the standpoint that will be a National Championship elimination game. These two teams are amongst the best in the nation, and they are both going to be up against it taking on the other in the biggest game for both over the course of the year. Unlike Texas, which is favored by more than home field advantage, the oddsmakers just can’t separate Georgia and South Carolina. The only difference to make this spread South Carolina -3? The fact that this game is being played in Columbia and not in Athens. Flip this one to Athens, and the Dawgs would probably be favored by a field goal right now as well.

**Click Here for the World’s Most Profitable Sports Betting System**

It’s not as though the rest of the card is going to be feature a ton of slacking games. There are a number of teams that are on massive upset alert that are ranked in the Top 25 in the country.

Perhaps the biggest upset candidate might be the Florida State Seminoles. The garnet and gold overcame their first road game of the year, and they are expected to do so against the NC State Wolfpack this week as well. However, Raleigh has always been a nightmarish place for the Noles to play in, and NC State has always been a thorn in FSU’s side. The Wolfpack are getting two touchdowns, but if recent history repeats itself, the Seminoles might be in some trouble. They have lost four meetings here in Raleigh since the late-1990s.

The Oklahoma Sooners might be on upset alert as well on the road. The Sooners were beaten by the Kansas State Wildcats at home the last time that we saw them, and now, their hopes of playing for the Big XII Championship or the BCS really at all are up in the air here in Lubbock on Saturday. The Texas Tech Red Raiders are the next team on the docket, and this game is dangerous for sure. Head Coach Tommy Tuberville is a master for games like this one, and his offense is going to be problematic for OU. Remember that last year, as more than four-touchdown underdogs, the Red Raiders pulled off the shocker in Norman. This year, T-Tech is getting just five points.

The Michigan Wolverines could be in some trouble as well. They aren’t in the Top 25 anymore, but they are certainly still supposed to be favorites to win the Big Ten. QB Denard Robinson has looked lost at times in this, his senior year, and now, he is going to be running into a Purdue Boilermakers outfit that was the only one this year to really give the Notre Dame Fighting Irish a run for their money for the full 60 minutes. Michigan is -3.5, but it wouldn’t be a shock at all if the Boilers started their Big Ten campaign on the right foot.

Last week, the biggest favorite, the Alabama Crimson Tide, were favored by 30.5 points. This week, that number has come down quite a bit. The only favorites that are greater than 21 points on the opening college football betting odds are the Oregon Ducks (-24.5 vs. Washington Huskies), Kansas State Wildcats (-24.5 vs. Kansas Jayhawks), and Louisiana Tech Bulldogs (-25 vs. UNLV Runnin’ Rebels). There aren’t all that many big time road favorites this week either. The Fresno State Bulldogs are -16 against the Colorado State Rams, while the Michigan State Spartans are -14.5 on the road against the Indiana Hoosiers. No other team is favored on the road by more than the 14 of Florida State.

On the flip side of that though, there are six games which are separated by a college football point spread of three points or fewer, while there are 19 games that are separated by a touchdown or fewer.

What’s most interesting to us is the role of the aforementioned Louisiana Tech Bulldogs. One more win should put the Bulldogs in the Top 25 in the land, and they are laying 25 points against the UNLV Running Rebels at home and should have no problem. Meanwhile, the only other mid-major team that has any sort of real chance to get into the BCS discussion this year is the Boise State Broncos, who are favored by 11 on the road against the Southern Mississippi Golden Eagles.

2012 NCAA Football Week 6 Odds @ WagerWeb Sportsbook (as of 10/6/12):
(Get a HUGE 100% Bonus at WagerWeb.com When Using This Link)

Week 6 College Football Betting Lines for Thursday, 10/4/12

303 East Carolina Pirates +12
304 Central Florida Knights -12
Over/Under 45

305 USC Trojans -13.5
306 Utah Utes +13.5
Over/Under 50

307 Arkansas State Red Wolves -1
308 Florida International Golden Panthers +1
Over/Under 56.5

NCAA Football Lines for Week 6 for Friday, 10/5/12

309 Pittsburgh Panthers +1
310 Syracuse Orange -1
Over/Under 59

311 Utah State Aggies +6.5
312 BYU Cougars -6.5
Over/Under 45

Week 6 NCAA Football Odds for Saturday, 10/6/12

313 Navy Midshipmen +8
314 Air Force Falcons -8
Over/Under 54

315 Michigan State Spartans -15.5
316 Indiana Hoosiers +15.5
Over/Under 48.5

317 Northern Illinois Huskies -2.5
318 Ball State Cardinals +2.5
Over/Under 66.5

319 Boston College Eagles -7
320 Army Black Knights +7
Over/Under 56.5

321 Bowling Green Falcons -5
322 Akron Zips +5
Over/Under 63.5

323 Miami Redhawks +20.5
324 Cincinnati Bearcats -20.5
Over/Under 58.5

325 Georgia Tech Yellow Jackets +10.5
326 Clemson Tigers -10.5
Over/Under 72.5

327 Virginia Cavaliers +1
328 Duke Blue Devils -1
Over/Under 55.5

329 South Florida Bulls -3.5
330 Temple Owls +3.5
Over/Under 47.5

331 Northwestern Wildcats +2.5
332 Penn State Nittany Lions -2.5
Over/Under 47.5

333 Kent State Golden Flashes -3
334 Eastern Michigan Eagles +3
Over/Under 48.5

335 Connecticut Huskies +7
336 Rutgers Scarlet Knights -7
Over/Under 40

337 Florida State Seminoles -15.5
338 NC State Wolfpack +15.5
Over/Under 54

339 Massachusetts Minutemen +16.5
340 Western Michigan Broncos -16.5
Over/Under 55

341 Vanderbilt Commodores +7
342 Missouri Tigers -7
Over/Under 44.5

343 Texas A&M Aggies -13.5
344 Ole Miss Rebels +13.5
Over/Under 64.5

345 Virginia Tech Hokies +5.5
346 North Carolina Tar Heels -5.5
Over/Under 50

347 Washington Huskies +24
348 Oregon Ducks -24
Over/Under 62.5

349 Georgia Bulldogs +1.5
350 South Carolina Gamecocks -1.5
Over/Under 54

351 West Virginia Mountaineers +7
352 Texas Longhorns -7
Over/Under 73.5

353 Iowa State Cyclones +7
354 TCU Horned Frogs -7
Over/Under 41

355 Illinois Fighting Illini +14.5
356 Wisconsin Badgers -14.5
Over/Under 45

357 Kansas Jayhawks +25
358 Kansas State Wildcats -25
Over/Under 54

359 UCLA Bruins -2.5
360 Cal Golden Bears +2.5
Over/Under 55.5

361 Arkansas Razorbacks +7
362 Auburn Tigers -7
Over/Under 56

363 Michigan Wolverines -2.5
364 Purdue Boilermakers +2.5
Over/Under 58

365 Wyoming Cowboys +19
366 Nevada Wolf Pack -19
Over/Under 68.5

367 New Mexico State Aggies +9.5
368 Idaho Vandals -9.5
Over/Under 56.5

369 Arizona Wildcats +9.5
370 Stanford Cardinal -9.5
Over/Under 54

371 Oklahoma Sooners -4
372 Texas Tech Red Raiders +4
Over/Under 57

373 Central Michigan Chippewas +11.5
374 Toledo Rockets -11.5
Over/Under 68

375 Boise State Broncos -10
376 Southern Miss Golden Eagles +10
Over/Under 47.5

377 Rice Owls -5.5
378 Memphis Tigers +5.5
Over/Under 61

379 Wake Forest Demon Deacons +7
380 Maryland Terrapins -7
Over/Under 47.5

381 Mississippi State Bulldogs -10
382 Kentucky Wildcats +10
Over/Under 46.5

383 Washington State Cougars +14.5
384 Oregon State Beavers -14.5
Over/Under 58.5

385 UNLV Runnin’ Rebels +27.5
386 Louisiana Tech Bulldogs -27.5
Over/Under 70

387 Tulsa Golden Hurricane -4
388 Marshall Thundering Herd +4
Over/Under 69

389 Miami Hurricanes +14
390 Notre Dame Fighting Irish -14
Over/Under 53.5

391 Buffalo Bulls +14
392 Ohio Bobcats -14
Over/Under 57

393 Nebraska Cornhuskers +3
394 Ohio State Buckeyes -3
Over/Under 56.5

395 Hawaii Warriors +21.5
396 San Diego State Aztecs -21.5
Over/Under 59.5

397 Fresno State Bulldogs -17.5
398 Colorado State Rams +17.5
Over/Under 60

399 LSU Tigers -2.5
400 Florida Gators +2.5
Over/Under 41.5

401 Texas State Bobcats +3
402 New Mexico Lobos -3
Over/Under 50

403 SMU Mustangs +2.5
404 UTEP Miners -2.5
Over/Under 51.5

405 Tulane Green Wave +27.5
406 Louisiana Lafayette Ragin’ Cajuns -27.5
Over/Under 54.5

407 Louisiana Monroe Warhawks -3
408 Middle Tennessee State Blue Raiders +3
Over/Under 66

409 North Texas Mean Green +11
410 Houston Cougars -11
Over/Under 58.5

441 Southeast Louisiana Golden Lions +18.5
442 UAB Blazers -18.5