Massive NFL point spreads are the theme of the Week 10 NFL betting lines, as there are a number of games that are expected to be blowouts. After one of the most public weeks in the history of NFL betting action though, we know that there are probably some NFL upsets that are going to be in the cards this coming week.

The team that opens up the weekend as the biggest favorite is the San Francisco 49ers. The Niners are coming off of their bye week, and they are taking on the easiest foe in their division, the St. Louis Rams. Head Coach Jeff Fisher and the gang aren’t going to go down easily, even if this game is played on the road and in front of one of the best crowds in the league. Still, getting 11.5 points is a ton to start with, and we have seen St. Louis stick around with some big time spreads on its side this year. The 49ers are most certainly on notice that this is going to be a tough game.

The other double digit favorites this week are the New England Patriots. The Pats have just rolled right through some foes this year, but the last we saw of them, they needed overtime to take down the Jets right here at Gillette Stadium in a similar game. The Brady Bunch is coming off of its bye week, and it gets a Buffalo Bills team that just isn’t all that great. The Bills were blasted by a dozen last week by the Texans on the road, and this is likely going to be the fourth massive beating that they have taken on the road this year.

One of the more intriguing early games on Sunday pits the Denver Broncos against the Carolina Panthers. Carolina is probably out of the playoff picture at this point in spite of last week’s win over the Redskins, but the interesting part of this is that Head Coach John Fox is returning to his old stomping grounds with his new and improved team. The Broncos are clearly one of the best teams in the AFC this year, but this is a long road trip against a team that is hungry and talented in spite of its iffy 2-6 record. Carolina is getting four points at home, and we can already tell that this is going to be the exact same situation that the Broncos were in last week when they beat the Cincinnati Bengals. These same Bengals are getting four for the second straight week at home against the New York Giants as well.

This is the week that the rubber might meet the road for a number of potential playoff teams in the AFC. The Miami Dolphins dipped to .500 last week, and they badly need to beat the Tennessee Titans at home as six-point favorites to keep their season alive. The Baltimore Ravens are also favored by 7.5 at M&T Bank Stadium against the Oakland Raiders, one of the hungriest teams in the league.

Thanks to Monday Night Football, this week still has two very important games that are listed as off the board. The New Orleans Saints are going to take on the Atlanta Falcons, and the truth of the matter is that QB Drew Brees and the gang very well could ultimately be favored over the 8-0 Falcons, who are still clearly getting no respect in spite of the fact that they very well could be halfway to a perfect season. The other game is going to see the Dallas Cowboys and Philadelphia Eagles go at each other. Both teams are still in the race in the NFC East, but neither has to feel comfortable right now. Both are on the outside of the playoffs looking in, and that makes this one all the more important. We expect to see the Eagles as short favorites in this game, though Dallas has been getting a lot of respect on the NFL odds of late.

And then there are the primetime games though, which are all going to be very important games. We’ll start on Thursday, when the Indianapolis Colts are three-point road favorites on the road against the Jacksonville Jaguars. The Jags are one of the worst teams in the league, and they are still going to be playing without RB Maurice Jones-Drew. However, Indy is the team of the hour, clearly, knowing that it has a chance to get to 6-3 this year and firmly in control of its own destiny for a spot in the playoffs this year.

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Football Night in America this week might be a Super Bowl 47 preview. The Chicago Bears and Houston Texans know that this game isn’t the end of the world at the moment, as both teams are clearly on their way to the playoffs, likely as division champs. The winner is going to feel a heck of a lot better than the loser though, knowing that Colts in the AFC South and the Packers and Vikings in the NFC North aren’t all that far off the heels of the two respective division leaders. This is expected to be one of the best games of the weekend, knowing that both of these teams are clearly in the Top 5 teams in all of football. The Bears are going to be laying 1.5 at the outset of the week at home, but this one clearly could go either way on the NFL point spreads.

Finally, Monday Night Football this week, could be a disaster for the Kansas City Chiefs and Head Coach Romeo Crennel. Poor Crennel hasn’t even been the coach for a full year of this team, but in the end, he is expected to get dismissed sooner than later. His team has been brutalized in virtually every spot this year, and the Chiefs haven’t even led for a single second in a game this year. Odds have it, this won’t be the week that this changes either, as the Pittsburgh Steelers are favored by 11.5 points against the Chiefs at Heinz Field.

‘Totals’ this week are going to be spread all over the place. As expected, the highest ‘total’ of the weekend to this point pits the Patriots against the Bills. We have seen New England’s offense score oodles of points against virtually anyone in the league, and we have seen the Bills give up at least 45 three times this year. That’s why this is featuring an over/under of 51. We do expect to see the Atlanta/New Orleans game featuring a ‘total’ in the 50s as well, quite possibly higher than this Buffalo/New England game as well.

The low end ‘totals’ of the weekend are both in the 30s, and that is relatively rare, knowing that the mass majority of games are in the 40s this year. The New York Jets and Seattle Seahawks are seeing their ‘total’ sitting at 38.5, while the same number is hanging on the board right now for the Rams and 49ers.

2012 NFL Week 10 Odds @ SportBet Sportsbook (as of 11/10/12):
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Week Ten NFL Lines for Thursday, November 8th
105 Indianapolis Colts -3
106 Jacksonville Jaguars +3
Over/Under 44

Week 10 NFL Spreads for Sunday, November 11th (1:00 ET Kickoffs)
215 Buffalo Bills +12
216 New England Patriots -12
Over/Under 52.5

217 New York Giants -3.5
218 Cincinnati Bengals +3.5
Over/Under 49

219 San Diego Chargers +3
220 Tampa Bay Buccaneers -3
Over/Under 47

221 Denver Broncos -4
222 Carolina Panthers +4
Over/Under 47

223 Tennessee Titans +6
224 Miami Dolphins -6
Over/Under 44

225 Oakland Raiders +9.5
226 Baltimore Ravens -9.5
Over/Under 47

227 Atlanta Falcons -1
228 New Orleans Saints +1
Over/Under 53.5

229 Detroit Lions -1
230 Minnesota Vikings +1
Over/Under 46

NFL Week 10 Betting Lines for Sunday, November 11th (4:00 ET Kickoffs)
231 New York Jets +6
232 Seattle Seahawks -6
Over/Under 38.5

233 Dallas Cowboys -1
234 Philadelphia Eagles +1
Over/Under 44

235 St. Louis Rams +11.5
236 San Francisco 49ers -11.5
Over/Under 38.5

Sunday Night Football Week Ten Lines for Sunday, November 11th
237 Houston Texans +1
238 Chicago Bears -1
Over/Under 40

Monday Night Football Week 10 Lines for Monday, October 12th
239 Kansas City Chiefs +11.5
240 Pittsburgh Steelers -11.5
Over/Under 42