It should be quite the interesting week of NFL betting action in Week 7, as some of the top teams in the league square off against one another with playoff positioning firmly being on the line. Don’t miss our look at the Week 7 odds and all of the NFL betting lines for this week.

There’s no game on the board this week that is more important than the clash between the Indianapolis Colts and the Denver Broncos. Simply put, this is the biggest regular season game that the Colts have played since moving to Baltimore. They are taking on their former QB Peyton Manning, a legend in Indianapolis and a man for whom many teenagers are named for both in Indiana and in Tennessee. You won’t find a more loved man in the city that doesn’t currently play for the Colts, and there is going to be a huge tribute to Manning for what he did in Indy prior to this game. It should be emotional for sure, and we expect that Manning is going to be in his element playing in his old home. The Broncos, who have the best team in football right now, are -6.5 in this one, and that makes them the second biggest road favorites of the weekend. This game also features a ‘total’ of 56, the highest of the weekend.

The other road favorites of note and substance this weekend are the San Diego Chargers and the Seattle Seahawks. The Seahawks take on the Arizona Cardinals on Thursday Night Football this week, while the Bolts are going against the winless (and hapless) Jacksonville Jaguars. Seattle is giving 5.5 in this one, which is a far cry from the 58-0 score that these two teams played to last year. Don’t be shocked if this one is about some payback in the NFC West, as the Cards can get within just one game of the division lead if they can pull off this shocker. Jacksonville meanwhile, is the biggest home underdog of the weekend, as it is a 7.5-point pup. However, with the Chargers flying across the country and playing at 10:00 AM local time game the week after playing on Monday Night Football, the deck is stacked in favor of the hosts. If there was ever a game in which Jacksonville was going to beat a good team, this would be the game.

And then there are some games this weekend that just look flat out weird. The San Francisco 49ers are only laying four on the road against the Tennessee Titans, who are still using QB Ryan Fitzpatrick at quarterback. Meanwhile, the Carolina Panthers are -6.5 and bordering on -7 at home against the St. Louis Rams in a battle of teams that, at least on paper, look relatively comparable. The Washington Redskins have a significantly worse record than the Chicago Bears, and the argument could be made that these two teams will finish nowhere near each other this year. However, off of their bye week, QB Robert Griffin III and the Redskins are only a pick ’em at home against Chicago, insinuating that this could be the best game of the day on the Week 7 betting lines. Perhaps the oddest of the odd? The New York Jets are only +3.5 at home against the New England Patriots, who feel like they should be favored by at least a TD in this one.

Not every game is complete lopsided by looks, though. The Houston Texans are in desperate need of a victory, and they are going to try to snap their four-game losing streak against the unbeaten Kansas City Chiefs. The Chiefs just broke the record for the loudest crowd road ever at an NFL game at 137.7 dB, and you know that this is going to be amped up for this game against the two-time defending AFC South champs. QB Matt Schaub is highly suspect at this point, and he is questionable for this game with a leg injury. The Houston offense needs any spark that it can get. The Texans are sharp for sure, and they are +6.5 on the road at Arrowhead. This game features the lowest ‘total’ of the day at 39.5, and it is one of the four games on the docket with ‘totals’ of 41 or lower, making it the lowest scoring week by average ‘total’ in NFL betting action this year.

The Detroit Lions and the Cincinnati Bengals were both laughing stocks for a number of years, but now, they are both division leaders with a chance to really put their foot down in their respective divisions. The Bengals are on the road at Ford Field, where they are getting 2.5, though Detroit is still wondering if it is going to have its best offensive weapon, WR Calvin Johnson ready to go in this game.

The Philadelphia Eagles are -2.5 at home with QB Nick Foles calling the shots against the Dallas Cowboys in a game where first place is on the line in the NFC East. The Miami Dolphins are -7.5 at home against the Buffalo Bills, who could be starting either QB Thad Lewis or the newly acquired QB Matt Flynn under center this week. The Tampa Bay Buccaneers are getting 7.5 against the Atlanta Falcons, who also have injury problems the likes of which you wouldn’t believe. When he gets in the huddle on Sunday, the only skill player that might be looking back at QB Matt Ryan that was starting the season in that huddle is TE Tony Gonzalez. WR Roddy White, WR Julio Jones, and RB Steven Jackson all expect to be sitting this one out.

In the 4:00 ET hour, the Pittsburgh Steelers are trying to salvage their season, something that they will be able to accomplish if they can beat the NFL betting lines against the Baltimore Ravens. The Steelers are -2.5 at home against the defending Super Bowl champs. Elsewhere, the Green Bay Packers, even without LB Clay Matthews and WR Randall Cobb, are -10.5 at home against the Cleveland Browns.

Sadly, the worst game of the week is probably the Monday Night Football game. The winless New York Giants are favored by 3.5 to get their first victory of the campaign against the one-win Minnesota Vikings, who are going to be starting QB Josh Freeman, marking their third starting quarterback thus far in six games on the season.

2013 NFL Week 7 Spreads @ SportBet Sportsbook (as of 10/17/13):
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Week 7 NFL Point Spreads for Thursday, October 17th
303 Seattle Seahawks -5.5
304 Arizona Cardinals +5.5
Over/Under 41

Week 7 NFL Lines for Sunday, October 20th (1:00 ET Kickoffs)
397 New England Patriots -3.5
398 New York Jets +3.5
Over/Under 43.5

399 San Diego Chargers -7.5
400 Jacksonville Jaguars +7.5
Over/Under 45.5

401 Houston Texans +6
402 Kansas City Chiefs -6
Over/Under 39.5

403 Cincinnati Bengals +2.5
404 Detroit Lions -2.5
Over/Under 47

405 Buffalo Bills +7.5
406 Miami Dolphins -7.5
Over/Under 42.5

407 Chicago Bears pk
408 Washington Redskins pk
Over/Under 50

409 Dallas Cowboys +2.5
410 Philadelphia Eagles -2.5
Over/Under 54.5

411 St. Louis Rams +6.5
412 Carolina Panthers -6.5
Over/Under 42

413 Tampa Bay Buccaneers +7.5
414 Atlanta Falcons -7.5
Over/Under 43

NFL Week 7 Lines for Sunday, October 20th (4:00 ET Kickoffs)
415 San Francisco 49ers -4
416 Tennessee Titans +4
Over/Under 40

417 Cleveland Browns +10.5
418 Green Bay Packers -10.5
Over/Under 46.5

419 Baltimore Ravens +2.5
420 Pittsburgh Steelers -2.5
Over/Under 41

Week 7 Sunday Night Football Lines for Sunday, October 20th
421 Denver Broncos -6.5
422 Indianapolis Colts +6.5
Over/Under 56

Monday Night Football Week 7 Spreads for Monday, October 21st
423 Minnesota Vikings +3.5
424 New York Giants -3.5
Over/Under 46.5