Week 4 of the 2014 college football season is upon us. Here are some of the marquee matchups and the lines for the upcoming weekend of action, courtesy of JustBet. All NCAA football bettors and sports fans will get their fill of quality action this weekend as there are quite a few interesting matchups on tap.

#5 Auburn (-9) at #20 Kansas State 7:30 PM ESPN

The #20 ranked Kansas State wildcats will need to be at the top of their game when they host the #5 ranked Auburn Tigers. Kansas State has had 2 weeks to prepare, and they’ll need it as Auburn is averaging 330 yards per game on the ground.

Georgia Tech at Virginia Tech  (-8) 12:00 PM ESPN

Virginia Tech was riding high after their upset win at Ohio State. They came back down to earth last weekend after a 28-21 upset loss to East Carolina. The Virginia Tech defense will now have to focus as they have the triple option attack of Georgia Tech to deal with.

Florida at #3 Alabama (-14) 3:30 PM CBS

The Florida Gators head to Tuscaloosa to take on the #3 ranked Alabama Crimson Tide. Florida escaped with a 36-30 win in triple overtime. The Crimson Tide has taken care of business since being tested by West Virginia in week 1, winning their last 2 games by a combined score of 93-10.

Virginia at #21 BYU (-15) 3:30 PM ESPN

The Virginia Cavaliers, fresh off their upset win of Louisville, will head to Provo, Utah to take on Taysom Hill and the #20 ranked BYU Cougars. This game will feature two of the better defensive units in the nation.

Jameis Winston passed for 444 yards and 3 touchdowns in a 51-14 win at Clemson last season

Mississippi State at #8 LSU 7:00 PM ESPN

The Mississippi State Bulldogs will have upset on their mind when they take on LSU from Baton Rouge, LA. LSU’s defense has not given up a score since their win against Wisconsin, and will look to replicate the 59-26 drubbing that they dealt the Bulldogs last year.

#4 Oklahoma (-7) at West Virginia 7:30 PM FOX

In what should be one of the better games of the weekend, the #4 ranked Oklahoma Sooners head to Morgantown to take on the improved West Virginia Mountaineers. It should be a stiff road test for the Sooners, as they will be in a hostile environment. Oklahoma won last year’s meeting 16-7, in Norman.

#22 Clemson at #1 Florida State  (-20) 8:00 PM ABC

Last year the Florida State Seminoles put the rest of college football on notice as they dominated Clemson on the Tigers’ home turf 51-14. The Tigers will need a better effort than what they showed in week 1, or it could result in the same outcome in Tallahassee.

Miami (FL) at #24 Nebraska (-7) 8:00 PM ESPN

The Nebraska Cornhuskers have been somewhat inconsistent this season. They had an impressive 55-7 win in week 1, and then needed a miracle play in week 2 to defeat McNeese State. The Miami Hurricanes should provide a stiff test, as they’ve looked a lot better in the past two weeks compared to their road opener loss to Louisville.

A great week on the Week 4 NFL betting lines is already getting started here at Bankroll Sports, and we are zeroing in on the best and the brightest NFL betting lines that are on the board for the week ahead!

Note: All NFL betting lines listed for the purposes of this article were posted at 6:00 p.m. ET on Sunday, 9/22. For the most up to date Week 4 NFL Vegas odds, please check below

Week 4’s Thursday Night Football game is going to be a doozy of a battle, as the San Francisco 49ers are going to take on the St. Louis Rams. These two teams could go back and forth with each other in the NFC West all season long. This is a crucial one for San Fran especially, which already lost a road game in division once this year from just two weeks ago. QB Colin Kaepernick and the gang have still looked good aside from that game against the Seahawks, but this is a big test on the road against a team that is ready for a bounceback after losing two straight suspect games. If St. Louis is going to get back into the chase in the NFC West, this is a game that it has to win. However, the Week 4 odds suggest that the 49ers are going to end up being at their best in this one, as they are favored by 3.5.

Fast forwarding to Sunday, we see that there are plenty of games that are expected to be close. In fact, there is only one game on the NFL opening lines where one team is favored by more than 7.5 points over another team, and that’s the clash on the road when the Denver Broncos take on the Philadelphia Eagles. QB Peyton Manning and the gang have looked great through two games thus far this year, and this should merely be a bump in the road. We’ll have to see how Head Coach Chip Kelly can get his team ready with an extended week of practice. Remember that this is the first time this year that the Eagles are playing a game on more than just five days of rest plus a day of travel, and they could be much better because of it. That said, going all the way to Mile High isn’t going to be fun for anyone this year, and it’s not surprising that in spite of that fact, the Eagles are getting 13. It’s going to be tough for this offense to get going in the thin air unless it is appropriately trained, and this is one thing that Kelly and QB Michael Vick couldn’t possibly be getting ready for in the City of Brotherly Love.

The only other game featuring NFL point spreads of greater than 6 is when the Indianapolis Colts, who look much better offensively with RB Trent Richardson in the fold, head to the Sunshine State to take on the Jacksonville Jaguars. Jacksonville has now been blown out by double digits in three straight games to start the season, and there is no turning back in this one. The Jags are +7.5, and this is a number that could get worse as the week goes on.

The one common thread that is apparent in Week 4 is the fact th that there are a ton of games that feature road favorites of varying degrees. We’ve already spoken about the Colts, but the Cincinnati Bengals are -5 at the Dawg Pound against the suddenly inspiring Cleveland Browns. Leave it up to Cleveland to trade its best player in RB Trent Richardson and find a way to win the next week with a backup quarterback. QB Brian Hoyer threw for 321 yards and three TDs last week, and that might create some real quarterback controversy for the Browns regardless of whether QB Brandon Weeden is healthy or not. Cincy is -5, but these divisional road games are always particularly tough, especially in the AFC North.

The Baltimore Ravens, fresh off of their upset over the Houston Texans last week, are going to be heading on the road this week to take on the Buffalo Bills, who badly need a win if they are going to stick around as potential contenders for the playoffs in the AFC. Baltimore is giving 4.5-points in spite of the fact that its offense really hasn’t done all that much impressive this year.

Perhaps the oddest spots for road favorites this week are on the West Coast against AFC West teams. Oh sure, the Dallas Cowboys have done everything that they can to deserve being -2 against the San Diego Chargers, but an 0-3 team traveling across the country is a favorite? That’s the situation that the Washington Redskins are in against the Oakland Raiders. Be very wary of this one, especially knowing that the buzzards are already starting to swarm around Head Coach Mike Shanahan.

The best game of the day on Sunday featuring a road favorite is the clash between the Seattle Seahawks and the Houston Texans. The Seahawks are looking the part of the best team in football right now, but this is a tough road trip against a Houston team that needs to prove that it can stick with the big boys. Remember last season when the Texans beat up the Ravens by 30 at home? This could be the same type of game if the Seahawks aren’t careful. That said, even on the road, Seattle is giving a field goal, and that could be a recipe for disaster for the visitors.

Elsewhere on Sunday on the NFL betting lines… The Tampa Bay Buccaneers are -3 against the Arizona Cardinals. The Kansas City Chiefs are six-point favorites to improve to 4-0 against the already 0-3 New York Giants. The Tennessee Titans are -5.5 at home against the New York Jets as well.

Sunday Night Football in Week 4 pits the New England Patriots up against the Atlanta Falcons. The Falcons still don’t totally look right, but they are going against a New England team that really hasn’t faced any quality opponent this year. On the road in primetime is going to be quite the test for QB Tom Brady and the gang, though we fully expect to see TE Rob Gronkowski back in this game for the Pats. That could be the great equalizer. New England is just a pick ’em in this clash of two teams that were expected to challenge on the Super Bowl odds this year.

On Monday Night Football, the New Orleans Saints are giving 4.5 to the Miami Dolphins. These two teams both missed out on the playoffs last year, but there is no doubt that both teams are going to be in a position to challenge this year in their respective divisions. Points could be aplenty in this one, especially knowing that QB Drew Brees is just 300 passing yards away from tying the record for the most consecutive 300+ yard games in NFL history. Brees is currently at eight. The NFL record is nine.

2013 NFL Week 4 Odds @ BetOWI Sportsbook (as of 9/25/13):
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Week 4 NFL Point Spreads for Thursday, September 26th
101 San Francisco 49ers -3
102 St. Louis Rams +3
Over/Under 42

Week 4 NFL Spreads for Sunday, September 29th (1:00 ET Kickoffs)
199 Pittsburgh Steelers -2.5
200 Minnesota Vikings +2.5
Over/Under 42

201 Baltimore Ravens -3
202 Buffalo Bills +3
Over/Under 44.5

203 Cincinnati Bengals -4
204 Cleveland Browns +4
Over/Under 42

205 Indianapolis Colts -7.5
206 Jacksonville Jaguars +7.5
Over/Under 42.5

207 Seattle Seahawks -2.5
208 Houston Texans +2.5
Over/Under 41.5

209 Arizona Cardinals +2
210 Tampa Bay Buccaneers -2
Over/Under 41

211 Chicago Bears +3
212 Detroit Lions -3
Over/Under 47.5

213 New York Giants +4.5
214 Kansas City Chiefs -4.5
Over/Under 44

NFL Week 4 Betting Lines for Sunday, September 29th (4:00 ET Kickoffs)
215 New York Jets +3.5
216 Tennesese Titans -3.5
Over/Under 39

217 Dallas Cowboys -2
218 San Diego Chargers +2
Over/Under 46.5

219 Washington Redskins -3
220 Oakland Raiders +3
Over/Under 43.5

221 Philadelphia Eagles +11
222 Denver Broncos -11
Over/Under 57.5

Sunday Night Football Week 4 Odds for Sunday, September 29th
223 New England Patriots +2
224 Atlanta Falcons -2
Over/Under 49.5

Monday Night Football Week 4 Lines for Monday, September 30th
225 Miami Dolphins +6.5
226 New Orleans Saints -6.5
Over/Under 48